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Lithium Synergy
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Manufacturer: Designs for Health
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Lithium Synergy™ combines lithium orotate, known
for its ability to help stabilize mood swings related to depression and
other mood disorders, with vitamin B12 (methylcobalamin) and
trimethylglycine to support healthy methylation pathways.
Observational studies have found as many as 30% of patients hospitalized
for depression are deficient in vitamin B12. The reasons for the
relationship between vitamin B12 deficiency and depression may involve
s-adenosylmethionine (SAMe). Vitamin B12 is required for the synthesis
of SAMe, a methyl group donor essential for methylation reactions and
subsequently the metabolism of neurotransmitters. SAMe deficiency has
been related to depression. This hypothesis is supported by several
studies that have shown supplementation with SAMe improves depressive
symptoms.
How does lithium orotate work?
Mood disorders are often due to inositol depletion. Lithium recycles and
synthesizes inositol by inhibiting IMPase enzyme. The phosphoinositol
signaling pathway is involved in cell membrane signaling cascades. When
salts of lithium are ingested, the lithium ions interact with several
neurotransmitters and receptors in the central nervous system resulting
in decreased norepinephrine release and increased serotonin synthesis.
Why add vitamin B12 and TMG (trimethylglycine)?
Vitamin B12 in the form of methylcobalamin and trimethylglycine both can
donate methyl groups to improve methylation, often a weakness in
patients with depression and other disorders.
Product Contains: Vitamin B12 (as Methylcobalamin) 250mcg, Lithium (as Lithium Orotate) 5mg, Trimethylglycine (TMG) 200mg
Other Ingredients: Microcrystalline cellulose, magnesium stearate
This product does not contain: wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars or preservatives.
Serving Size: 1 capsule
Recommended Use: The recommended dose for most applications is 1-4 capsules per day in divided doses with or without food.
Caution: Taking patients off of prescription lithium may result in a
rebound effect. Lithium levels should be monitored by a qualified health
care professional.
This product should not be used to replace
any anti-depressant medication, including prescription forms of lithium,
unless under the direction of a qualified health care practitioner.
Lithium should not be used by individuals with significant renal or
cardiovascular diseases, severe debilitation or dehydration, or sodium
depletion, or by individuals who are taking diuretics or ACE inhibitors.
Consult your doctor before use if you are taking anti-hypertensive
drugs, anti-inflammatory drugs, analgesic drugs or insulin. Lithium
should not be used by pregnant women and breast-feeding mothers. Serum
lithium levels should be monitored by a qualified health care provider
during use.
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